Jump to main content
Jump to site search

Issue 83, 2013
Previous Article Next Article

Covalent modification of cell surfaces with TLR agonists improves & directs immune stimulation

Author affiliations

Abstract

We present a primary example of a cell surface modified with a synergistic combination of agonists to tune immune stimulation. A model cell line, Lewis Lung Carcinoma, was covalently modified with CpG-oligonucleotides and lipoteichoic acid, both Toll-like receptor (TLR) agonists. The immune-stimulating constructs provided greater stimulation of NF-κB in a model cell line and bone marrow-derived dendritic cells than the components unconjugated in solution.

Graphical abstract: Covalent modification of cell surfaces with TLR agonists improves & directs immune stimulation

Back to tab navigation

Supplementary files

Publication details

The article was received on 19 Jul 2013, accepted on 26 Aug 2013 and first published on 27 Aug 2013


Article type: Communication
DOI: 10.1039/C3CC45468A
Citation: Chem. Commun., 2013,49, 9618-9620
  •   Request permissions

    Covalent modification of cell surfaces with TLR agonists improves & directs immune stimulation

    J. K. Tom, R. J. Mancini and A. P. Esser-Kahn, Chem. Commun., 2013, 49, 9618
    DOI: 10.1039/C3CC45468A

Search articles by author

Spotlight

Advertisements