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Issue 78, 2013
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Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds

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Abstract

We have combined the benefits of both microfluidics and flow hydrogenation to provide facile access to previously underutilized reduction and protecting group chemistries for PET imaging applications. The rapid removal of an O-benzyl protecting group to prepare 2-[18F]fluoroquinolin-8-ol and the reduction of a nitro group in the synthesis of 4-[18F]fluoroaniline were achieved within 3 minutes.

Graphical abstract: Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds

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Publication details

The article was received on 09 Jul 2013, accepted on 25 Jul 2013 and first published on 29 Jul 2013


Article type: Communication
DOI: 10.1039/C3CC45166F
Citation: Chem. Commun., 2013,49, 8755-8757
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    Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds

    S. H. Liang, T. L. Collier, B. H. Rotstein, R. Lewis, M. Steck and N. Vasdev, Chem. Commun., 2013, 49, 8755
    DOI: 10.1039/C3CC45166F

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