Issue 78, 2013

Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds

Abstract

We have combined the benefits of both microfluidics and flow hydrogenation to provide facile access to previously underutilized reduction and protecting group chemistries for PET imaging applications. The rapid removal of an O-benzyl protecting group to prepare 2-[18F]fluoroquinolin-8-ol and the reduction of a nitro group in the synthesis of 4-[18F]fluoroaniline were achieved within 3 minutes.

Graphical abstract: Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds

Supplementary files

Article information

Article type
Communication
Submitted
09 Jul 2013
Accepted
25 Jul 2013
First published
29 Jul 2013

Chem. Commun., 2013,49, 8755-8757

Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds

S. H. Liang, T. L. Collier, B. H. Rotstein, R. Lewis, M. Steck and N. Vasdev, Chem. Commun., 2013, 49, 8755 DOI: 10.1039/C3CC45166F

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