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Issue 40, 2014
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The STIL protein contains intrinsically disordered regions that mediate its protein–protein interactions

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Abstract

The STIL protein participates in mitosis and malignant transformation by regulating centrosomal duplication. Using biophysical methods we studied the structure and interactions of STIL. We revealed that its central domain is intrinsically disordered and mediates protein–protein interactions of STIL. The intrinsic disorder may provide STIL with the conformational flexibility required for its multitude binding.

Graphical abstract: The STIL protein contains intrinsically disordered regions that mediate its protein–protein interactions

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Publication details

The article was received on 07 Jul 2013, accepted on 29 Aug 2013 and first published on 30 Aug 2013


Article type: Communication
DOI: 10.1039/C3CC45096A
Citation: Chem. Commun., 2014,50, 5245-5247
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    The STIL protein contains intrinsically disordered regions that mediate its protein–protein interactions

    H. Amartely, A. David, M. Lebendiker, H. Benyamini, S. Izraeli and A. Friedler, Chem. Commun., 2014, 50, 5245
    DOI: 10.1039/C3CC45096A

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