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Issue 95, 2013
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Water-soluble non-aggregating zinc phthalocyanine and in vitro studies for photodynamic therapy

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Abstract

Newly synthesized zinc phthalocyanine bearing sixteen quaternized imidazolyl moieties on the periphery displays high water-solubility, lack of aggregation and high singlet oxygen quantum yield in water (ΦΔ > 0.33). The in vitro tests indicated excellent anticancer photodynamic activity (EC50 = 36.7 nM) and low dark toxicity to non-cancerous cells (TC50 = 395 μM).

Graphical abstract: Water-soluble non-aggregating zinc phthalocyanine and in vitro studies for photodynamic therapy

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Publication details

The article was received on 19 Jun 2013, accepted on 30 Aug 2013 and first published on 30 Aug 2013


Article type: Communication
DOI: 10.1039/C3CC44609C
Citation: Chem. Commun., 2013,49, 11149-11151
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    Water-soluble non-aggregating zinc phthalocyanine and in vitro studies for photodynamic therapy

    S. Makhseed, M. Machacek, W. Alfadly, A. Tuhl, M. Vinodh, T. Simunek, V. Novakova, P. Kubat, E. Rudolf and P. Zimcik, Chem. Commun., 2013, 49, 11149
    DOI: 10.1039/C3CC44609C

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