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Issue 72, 2013
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Site-specific cellular delivery of quantum dots with chemoselectively-assembled modular peptides

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Abstract

Modular peptides displaying both quantum dot bioconjugation motifs and specific subcellular targeting domains were constructed using a chemoselective aniline-catalyzed hydrazone coupling chemistry. Peptides were ratiometrically assembled onto quantum dots to facilitate their specific delivery to either the plasma membrane, endosomes, the cytosol or the mitochondria of target cells.

Graphical abstract: Site-specific cellular delivery of quantum dots with chemoselectively-assembled modular peptides

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Publication details

The article was received on 15 Apr 2013, accepted on 24 May 2013 and first published on 12 Jun 2013


Article type: Communication
DOI: 10.1039/C3CC42781A
Citation: Chem. Commun., 2013,49, 7878-7880
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    Site-specific cellular delivery of quantum dots with chemoselectively-assembled modular peptides

    J. B. Delehanty, J. B. Blanco-Canosa, C. E. Bradburne, K. Susumu, M. H. Stewart, D. E. Prasuhn, P. E. Dawson and I. L. Medintz, Chem. Commun., 2013, 49, 7878
    DOI: 10.1039/C3CC42781A

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