Issue 50, 2013
From the journal:

Chemical Communications

Ru(ii)-catalyzed intermolecular C–H amidation of weakly coordinating ketones†

Qing-Zhong Zheng,a   Yu-Feng Liang,a   Chong Qina  and  Ning Jiao*ab  

* Corresponding authors

a State Key Laboratory of Natural and Biomimetic Drugs, Peking University, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191, China
E-mail: jiaoning@bjmu.edu.cn
Web: http://sklnbd.bjmu.edu.cn/nj
Fax: +86-010-8280-5297
Tel: +86-010-8280-5297

b Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China

Abstract

An efficient Ru(II)-catalyzed intermolecular amidation of weakly coordinating ketones with sulfonyl azides via C–H bond activation is described. The reaction proceeds with high functional group tolerance, providing a novel approach to practical ketone-directed intermolecular C–N bond formation in the absence of an additional oxidant.

Graphical abstract: Ru(ii)-catalyzed intermolecular C–H amidation of weakly coordinating ketones

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Article information

DOI
https://doi.org/10.1039/C3CC42613K
Article type
Communication
Submitted
10 Apr 2013
Accepted
01 May 2013
First published
01 May 2013

Chem. Commun., 2013,49, 5654-5656

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Ru(II)-catalyzed intermolecular C–H amidation of weakly coordinating ketones

Q. Zheng, Y. Liang, C. Qin and N. Jiao, Chem. Commun., 2013, 49, 5654 DOI: 10.1039/C3CC42613K

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