Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Tuesday 19th September 2017 from 8.00am to 4.00pm (BST).

During this time our website performance may be temporarily affected. If you have any questions please use the feedback button available under our menu button. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 50, 2013
Previous Article Next Article

11CO2 fixation: a renaissance in PET radiochemistry

Author affiliations

Abstract

Carbon-11 labelled carbon dioxide is the cyclotron-generated feedstock reagent for most positron emission tomography (PET) tracers using this radionuclide. Most carbon-11 labels, however, are installed using derivative reagents generated from [11C]CO2. In recent years, [11C]CO2 has seen a revival in applications for the direct incorporation of carbon-11 into functional groups such as ureas, carbamates, oxazolidinones, carboxylic acids, esters, and amides. This review summarizes classical [11C]CO2 fixation strategies using organometallic reagents and then focuses on newly developed methods that employ strong organic bases to reversibly capture [11C]CO2 into solution, thereby enabling highly functionalized labelled compounds to be prepared. Labelled compounds and radiopharmaceuticals that have been translated to the clinic are highlighted.

Graphical abstract: 11CO2 fixation: a renaissance in PET radiochemistry

Back to tab navigation

Publication details

The article was received on 27 Mar 2013, accepted on 01 May 2013 and first published on 01 May 2013


Article type: Feature Article
DOI: 10.1039/C3CC42236D
Citation: Chem. Commun., 2013,49, 5621-5629
  •   Request permissions

    11CO2 fixation: a renaissance in PET radiochemistry

    B. H. Rotstein, S. H. Liang, J. P. Holland, T. L. Collier, J. M. Hooker, A. A. Wilson and N. Vasdev, Chem. Commun., 2013, 49, 5621
    DOI: 10.1039/C3CC42236D

Search articles by author

Spotlight

Advertisements