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Issue 50, 2013
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11CO2 fixation: a renaissance in PET radiochemistry

Benjamin H. Rotstein,a  Steven H. Liang,a  Jason P. Holland,a  Thomas Lee Collier,ab  Jacob M. Hooker,c  Alan A. Wilsond  and  Neil Vasdev*a 
Author affiliations

* Corresponding authors

a Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, and Department of Radiology, Harvard Medical School, 55 Fruit Street, Boston, USA
E-mail: vasdev.neil@mgh.harvard.edu
Fax: +1 617-726-6165
Tel: +1 617-643-4736

b Advion Inc., 10 Brown Road, Ithaca, USA

c Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA

d Research Imaging Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, 250 College Street, Toronto, Canada

Abstract

Carbon-11 labelled carbon dioxide is the cyclotron-generated feedstock reagent for most positron emission tomography (PET) tracers using this radionuclide. Most carbon-11 labels, however, are installed using derivative reagents generated from [11C]CO2. In recent years, [11C]CO2 has seen a revival in applications for the direct incorporation of carbon-11 into functional groups such as ureas, carbamates, oxazolidinones, carboxylic acids, esters, and amides. This review summarizes classical [11C]CO2 fixation strategies using organometallic reagents and then focuses on newly developed methods that employ strong organic bases to reversibly capture [11C]CO2 into solution, thereby enabling highly functionalized labelled compounds to be prepared. Labelled compounds and radiopharmaceuticals that have been translated to the clinic are highlighted.

Graphical abstract: 11CO2 fixation: a renaissance in PET radiochemistry

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Publication details

The article was received on 27 Mar 2013, accepted on 01 May 2013 and first published on 01 May 2013


Article type: Feature Article
DOI: 10.1039/C3CC42236D
Citation: Chem. Commun., 2013,49, 5621-5629
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    11CO2 fixation: a renaissance in PET radiochemistry

    B. H. Rotstein, S. H. Liang, J. P. Holland, T. L. Collier, J. M. Hooker, A. A. Wilson and N. Vasdev, Chem. Commun., 2013, 49, 5621
    DOI: 10.1039/C3CC42236D

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