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Issue 45, 2013
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Multivalent alteration of quorum sensing in Staphylococcus aureus

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Abstract

Virulence in Staphylococcus aureus is strongly and positively correlated with local cell density. Here we present an effective approach to modulate this group behaviour using multivalent peptidepolymer conjugates. Our results show that by attaching multiple AIP-4′ units to macromolecular scaffolds, the agr QS response in S. aureus was affected strongly, while displaying a clear multivalency effect.

Graphical abstract: Multivalent alteration of quorum sensing in Staphylococcus aureus

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Publication details

The article was received on 04 Mar 2013, accepted on 16 Apr 2013 and first published on 17 Apr 2013


Article type: Communication
DOI: 10.1039/C3CC41645C
Citation: Chem. Commun., 2013,49, 5177-5179
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    Multivalent alteration of quorum sensing in Staphylococcus aureus

    S. Melamed Yerushalmi, M. E. Buck, D. M. Lynn, N. G. Lemcoff and M. M. Meijler, Chem. Commun., 2013, 49, 5177
    DOI: 10.1039/C3CC41645C

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