Issue 45, 2013

Multivalent alteration of quorum sensing in Staphylococcus aureus

Abstract

Virulence in Staphylococcus aureus is strongly and positively correlated with local cell density. Here we present an effective approach to modulate this group behaviour using multivalent peptidepolymer conjugates. Our results show that by attaching multiple AIP-4′ units to macromolecular scaffolds, the agr QS response in S. aureus was affected strongly, while displaying a clear multivalency effect.

Graphical abstract: Multivalent alteration of quorum sensing in Staphylococcus aureus

Supplementary files

Article information

Article type
Communication
Submitted
04 Mar 2013
Accepted
16 Apr 2013
First published
17 Apr 2013

Chem. Commun., 2013,49, 5177-5179

Multivalent alteration of quorum sensing in Staphylococcus aureus

S. Melamed Yerushalmi, M. E. Buck, D. M. Lynn, N. G. Lemcoff and M. M. Meijler, Chem. Commun., 2013, 49, 5177 DOI: 10.1039/C3CC41645C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements