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Issue 45, 2013
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Nona-copper(II)-containing 18-tungsto-8-arsenate(III) exhibits antitumor activity

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Abstract

The nona-CuII-containing tungstoarsenate(III) [H4{CuII9AsIII6O15(H2O)6}(α-AsIIIW9O33)2]8− (1a) has been synthesized and characterized. Polyanion 1a comprises a unique, cylindrical {CuII9AsIII6O15(H2O)6}6+ cluster, which forms a large central cavity and is capped on either end by an [α-AsIIIW9O33]9− capping group. It exhibits remarkable activity against K562 leukaemia cells, as well as induces HepG2 cell apoptosis and autophagy.

Graphical abstract: Nona-copper(ii)-containing 18-tungsto-8-arsenate(iii) exhibits antitumor activity

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Publication details

The article was received on 04 Mar 2013, accepted on 18 Apr 2013 and first published on 18 Apr 2013


Article type: Communication
DOI: 10.1039/C3CC41628C
Citation: Chem. Commun., 2013,49, 5189-5191
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    Nona-copper(II)-containing 18-tungsto-8-arsenate(III) exhibits antitumor activity

    Z. Zhou, D. Zhang, L. Yang, P. Ma, Y. Si, U. Kortz, J. Niu and J. Wang, Chem. Commun., 2013, 49, 5189
    DOI: 10.1039/C3CC41628C

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