Issue 40, 2013

PPh3-mediated intramolecular conjugation of alkyl halides with electron-deficient olefins: facile synthesis of chromans and relevant analogues

Abstract

With the mediation of phosphine, the direct intramolecular coupling of two electrophiles – alkyl halides with electron-deficient olefins – has been successfully realized in an intramolecular conjugate addition manner. The reaction provides a new approach for the synthesis of chromans and relevant analogues.

Graphical abstract: PPh3-mediated intramolecular conjugation of alkyl halides with electron-deficient olefins: facile synthesis of chromans and relevant analogues

Supplementary files

Article information

Article type
Communication
Submitted
25 Feb 2013
Accepted
28 Mar 2013
First published
28 Mar 2013

Chem. Commun., 2013,49, 4570-4572

PPh3-mediated intramolecular conjugation of alkyl halides with electron-deficient olefins: facile synthesis of chromans and relevant analogues

J. Zhu, P. Wang, S. Liao and Y. Tang, Chem. Commun., 2013, 49, 4570 DOI: 10.1039/C3CC41435C

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