Issue 47, 2013
From the journal:

Chemical Communications

Luminescent organoplatinum(ii) complexes containing bis(N-heterocyclic carbene) ligands selectively target the endoplasmic reticulum and induce potent photo-toxicity†

Taotao Zou,a   Chun-Nam Lok,a   Yi Man Eva Funga  and  Chi-Ming Che*ab  

* Corresponding authors

a State Key Laboratory of Synthetic Chemistry, Institute of Molecular Functional Materials, Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong
E-mail: cmche@hku.hk
Fax: +852 2857 1586
Tel: +852 2857 2154

b HKU Shenzhen Institute of Research and Innovation, Shenzhen 518053, China

Abstract

A panel of luminescent platinum(II) complexes containing bidentate N-heterocyclic carbene ligands selectively localize to the endoplasmic reticulum (ER) domain, induce ER stress and cell apoptosis. Some of them show potent photo-toxicity to cancer cells.

Graphical abstract: Luminescent organoplatinum(ii) complexes containing bis(N-heterocyclic carbene) ligands selectively target the endoplasmic reticulum and induce potent photo-toxicity

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Article information

DOI
https://doi.org/10.1039/C3CC40953H
Article type
Communication
Submitted
04 Feb 2013
Accepted
11 Mar 2013
First published
21 Mar 2013

Chem. Commun., 2013,49, 5423-5425

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Luminescent organoplatinum(II) complexes containing bis(N-heterocyclic carbene) ligands selectively target the endoplasmic reticulum and induce potent photo-toxicity

T. Zou, C. Lok, Y. M. E. Fung and C. Che, Chem. Commun., 2013, 49, 5423 DOI: 10.1039/C3CC40953H

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