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Issue 77, 2013
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Cinchonine and thiourea

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Abstract

In this viewpoint, we discuss the seminal work contributed by Dixon, who reported the first use of a bifunctional cinchona-derived thiourea organocatalyst for the enantioselective conjugate addition of malonate esters to nitroalkenes. Since then, this class of catalysts has been extensively utilized in a variety of fundamental transformations. We also highlight here some of the representative studies performed since the publication of this milestone work in 2005.

Graphical abstract: Cinchonine and thiourea

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Publication details

The article was received on 31 Jan 2013, accepted on 30 Jul 2013 and first published on 31 Jul 2013


Article type: Viewpoint
DOI: 10.1039/C3CC40825F
Citation: Chem. Commun., 2013,49, 8583-8585
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    Cinchonine and thiourea

    Y. Xi and X. Shi, Chem. Commun., 2013, 49, 8583
    DOI: 10.1039/C3CC40825F

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