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Issue 27, 2013
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Diastereoselective synthesis of pyrrolidine derivatives via a one-pot nitro-Mannich/hydroamination cascade using base and gold catalysis

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Abstract

An efficient one-pot nitro-Mannich/hydroamination cascade reaction for the synthesis of substituted pyrrolidines bearing three stereocentres is reported. Proceeding under the control of a combination of base and gold(I) catalysts, the cascade reaction affords the pyrrolidine products in high yields with good to excellent diastereoselectivities.

Graphical abstract: Diastereoselective synthesis of pyrrolidine derivatives via a one-pot nitro-Mannich/hydroamination cascade using base and gold catalysis

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Publication details

The article was received on 28 Jan 2013, accepted on 18 Feb 2013 and first published on 18 Feb 2013


Article type: Communication
DOI: 10.1039/C3CC40729B
Citation: Chem. Commun., 2013,49, 2777-2779
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    Diastereoselective synthesis of pyrrolidine derivatives via a one-pot nitro-Mannich/hydroamination cascade using base and gold catalysis

    A. Ďuriš, D. M. Barber, H. J. Sanganee and D. J. Dixon, Chem. Commun., 2013, 49, 2777
    DOI: 10.1039/C3CC40729B

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