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Issue 40, 2013
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An engineered nanoplatform for bimodal anticancer phototherapy with dual-color fluorescence detection of sensitizers

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Abstract

A multifunctional nanoplatform with four-in-one photoresponsive functionalities has been achieved through the co-encapsulation of two chromo-fluorogenic components within biocompatible polymeric nanoparticles. This engineered nanoconstruct efficiently delivers different photosensitizers in melanoma cells, which can be detected through their dual-color fluorescence, and induces amplified cell mortality due to the simultaneous photogeneration of singlet oxygen and nitric oxide.

Graphical abstract: An engineered nanoplatform for bimodal anticancer phototherapy with dual-color fluorescence detection of sensitizers

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Publication details

The article was received on 28 Jan 2013, accepted on 28 Mar 2013 and first published on 28 Mar 2013


Article type: Communication
DOI: 10.1039/C3CC40714D
Citation: Chem. Commun., 2013,49, 4459-4461
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    An engineered nanoplatform for bimodal anticancer phototherapy with dual-color fluorescence detection of sensitizers

    A. Fraix, N. Kandoth, I. Manet, V. Cardile, A. C. E. Graziano, R. Gref and S. Sortino, Chem. Commun., 2013, 49, 4459
    DOI: 10.1039/C3CC40714D

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