Issue 26, 2013
From the journal:

Chemical Communications

Macromolecular prodrugs of ribavirin combat side effects and toxicity with no loss of activity of the drug†‡

Mille B. L. Kryger,ab   Benjamin M. Wohl,ab   Anton A. A. Smithb  and  Alexander N. Zelikin*ab  

* Corresponding authors

a Interdisciplinary Nanoscience Centre (iNANO), The iNANO House, Gustav Wieds Vej 14, DK-8000 Aarhus C, Denmark

b Department of Chemistry, Langelandsgade 140, DK-8000 Aarhus C, Denmark
E-mail: zelikin@chem.au.dk
Tel: +45 8715 5348

Abstract

Chemi-enzymatic synthesis of ribavirin acrylate and subsequent RAFT co-polymerization with acrylic acid afforded a formulation of a broad spectrum antiviral drug which avoids accumulation in erythrocytes, the origin of the main side effect of ribavirin. In cultured macrophages the macromolecular prodrugs exhibited decreased toxicity while maintaining the anti-inflammatory action of ribavirin.

Graphical abstract: Macromolecular prodrugs of ribavirin combat side effects and toxicity with no loss of activity of the drug

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Article information

DOI
https://doi.org/10.1039/C3CC00315A
Article type
Communication
Submitted
14 Jan 2013
Accepted
07 Feb 2013
First published
08 Feb 2013

Chem. Commun., 2013,49, 2643-2645

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Macromolecular prodrugs of ribavirin combat side effects and toxicity with no loss of activity of the drug

M. B. L. Kryger, B. M. Wohl, A. A. A. Smith and A. N. Zelikin, Chem. Commun., 2013, 49, 2643 DOI: 10.1039/C3CC00315A

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