A PdAg bimetallic nanocatalyst for selective reductive amination of nitroarenes

Linsen Li; Zhiqiang Niu; Shuangfei Cai; Yun Zhi; Hao Li; Hongpan Rong; Lichen Liu; Lei Liu; Wei He; Yadong Li

doi:10.1039/C3CC00249G

A PdAg bimetallic nanocatalyst for selective reductive amination of nitroarenes†

Linsen Li,^a Zhiqiang Niu,^a Shuangfei Cai,^a Yun Zhi,^bc Hao Li,^a Hongpan Rong,^a Lichen Liu,^a Lei Liu,^a Wei He*^bc and Yadong Li*^a

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^a Department of Chemistry, Tsinghua University, Beijing, P.R. China
E-mail: ydli@mail.tsinghua.edu.cn
Fax: +86-10-62788765
Tel: +86-10-62772350

^b Tsinghua-Peking Joint Center for Life Sciences, Tsinghua University, Beijing, P.R. China

^c School of Medicine, Tsinghua University, Beijing, P.R. China
E-mail: whe@mail.tsinghua.edu.cn

Abstract

Herein we have identified an optimal catalyst, Pd₁Ag_1.7, for the tandem reductive amination between nitroarenes and aldehydes (selectivity > 93%). Key to the success is the ability to control the compositions of the investigational Pd_1−xAg_x (x = 0–1) catalysts, as well as the clear composition dependent activity/selectivity trend observed in this study. This catalyst features a wide substrate scope, excellent recyclability, activity and selectivity under ambient conditions.

Chemical Communications

A PdAg bimetallic nanocatalyst for selective reductive amination of nitroarenes†

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A PdAg bimetallic nanocatalyst for selective reductive amination of nitroarenes

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