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Issue 12, 2013
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First one-pot organocatalytic synthesis of α-methylene-γ-lactones

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Abstract

All in one pot: an organocatalytic highly enantioselective synthesis of α-methylene-γ-lactones has been reported. The reaction between protected 2-hydroxymalonates and MBH carbonates is simply catalysed by chiral Lewis bases affording after acid treatment the corresponding lactones in excellent yields and enantioselectivities.

Graphical abstract: First one-pot organocatalytic synthesis of α-methylene-γ-lactones

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Publication details

The article was received on 03 Dec 2012, accepted on 18 Dec 2012 and first published on 19 Dec 2012


Article type: Communication
DOI: 10.1039/C2CC38659C
Citation: Chem. Commun., 2013,49, 1184-1186
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    First one-pot organocatalytic synthesis of α-methylene-γ-lactones

    X. Companyó, A. Mazzanti, A. Moyano, A. Janecka and R. Rios, Chem. Commun., 2013, 49, 1184
    DOI: 10.1039/C2CC38659C

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