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Issue 14, 2013
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A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation

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Abstract

This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of γ-glutamyl transpeptidase (γ-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).

Graphical abstract: A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation

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Publication details

The article was received on 21 Nov 2012, accepted on 20 Dec 2012 and first published on 21 Dec 2012


Article type: Communication
DOI: 10.1039/C2CC38382A
Citation: Chem. Commun., 2013,49, 1389-1391
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    A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation

    Q. Zhang, A. Kulczynska, D. J. Webb, I. L. Megson and N. P. Botting, Chem. Commun., 2013, 49, 1389
    DOI: 10.1039/C2CC38382A

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