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Issue 4, 2013
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Synthesis of ε-N-propionyl-, ε-N-butyryl-, and ε-N-crotonyl-lysine containing histone H3 using the pyrrolysine system

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Abstract

Recently new lysine modifications were detected in histones and other proteins. Using the pyrrolysine amber suppression system we genetically inserted three of the new amino acids ε-N-propionyl-, ε-N-butyryl-, and ε-N-crotonyl-lysine site specifically into histone H3. The lysine at position 9 (H3 K9), which is known to be highly modified in chromatin, was replaced by these unnatural amino acids.

Graphical abstract: Synthesis of ε-N-propionyl-, ε-N-butyryl-, and ε-N-crotonyl-lysine containing histone H3 using the pyrrolysine system

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Publication details

The article was received on 29 Oct 2012, accepted on 14 Nov 2012 and first published on 15 Nov 2012


Article type: Communication
DOI: 10.1039/C2CC37836A
Citation: Chem. Commun., 2013,49, 379-381
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    Synthesis of ε-N-propionyl-, ε-N-butyryl-, and ε-N-crotonyl-lysine containing histone H3 using the pyrrolysine system

    M. J. Gattner, M. Vrabel and T. Carell, Chem. Commun., 2013, 49, 379
    DOI: 10.1039/C2CC37836A

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