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Issue 10, 2013
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Hydrogen-bonding controlled rigidity of an isoindoline-derived nitroxide spin label for nucleic acids

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Abstract

Nucleosides spin-labelled with isoindoline-derived benzimidazole (ImU) and benzoxazole (OxU) moieties were synthesized and incorporated into DNA oligonucleotides. Both labels display limited mobility in duplex DNA but ImU was less mobile, which was attributed to an intramolecular hydrogen bond between the N–H of the imidazole and O4 of the uracil nucleobase.

Graphical abstract: Hydrogen-bonding controlled rigidity of an isoindoline-derived nitroxide spin label for nucleic acids

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Publication details

The article was received on 02 Sep 2012, accepted on 21 Nov 2012 and first published on 19 Dec 2012


Article type: Communication
DOI: 10.1039/C2CC36389E
Citation: Chem. Commun., 2013,49, 999-1001
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    Hydrogen-bonding controlled rigidity of an isoindoline-derived nitroxide spin label for nucleic acids

    D. B. Gophane and S. Th. Sigurdsson, Chem. Commun., 2013, 49, 999
    DOI: 10.1039/C2CC36389E

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