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Issue 23, 2013
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Direct mass spectrometry analysis of untreated samples of ultralow amounts using extraction nano-electrospray

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Abstract

Direct mass spectrometry analysis of untreated samples of volumes as low as 0.2 μL was achieved using fast extraction and nanoESI (electrospray ionization) in a combined fashion. The analytes in dried samples on paper substrates were extracted by an organic solvent in a nanoESI tube and ionized with a high voltage applied for generating a spray. The ionization source produced stable signals for different atmospheric pressure interfaces of triple quadrupole instruments. Analysis times more than 20 minutes were available with 10 μL solvent consumed for the entire analysis process. The performance in qualitative and quantitative analyses was characterized with a wide variety of samples. Limits of detection as low as 0.1 ng mL−1 (corresponding to an absolute amount of 0.05 pg) were obtained for analysis of atrazine in river water, thiabendazole in orange homogenate, and methamphetamine in blood.

Graphical abstract: Direct mass spectrometry analysis of untreated samples of ultralow amounts using extraction nano-electrospray

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Publication details

The article was received on 11 Jul 2013, accepted on 20 Sep 2013 and first published on 20 Sep 2013


Article type: Paper
DOI: 10.1039/C3AY41149D
Citation: Anal. Methods, 2013,5, 6686-6692
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    Direct mass spectrometry analysis of untreated samples of ultralow amounts using extraction nano-electrospray

    Y. Ren, J. Liu, L. Li, M. N. McLuckey and Z. Ouyang, Anal. Methods, 2013, 5, 6686
    DOI: 10.1039/C3AY41149D

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