Issue 16, 2013
From the journal:

Analyst

Ratiometric and absolute water-soluble fluorescent tripodal zinc sensor and its application in killing human lung cancer cells†

Shyamaprosad Goswami,*a   Avijit Kumar Das,a   Krishnendu Aich,a   Abhishek Manna,a   Sibaprasad Maity,a   Kalyani Khanrab  and  Nandan Bhattacharyyab  

* Corresponding authors

a Department of Chemistry, Bengal Engineering and Science University, Shibpur, Howrah, 711103, West Bengal, India
E-mail: spgoswamical@yahoo.com
Fax: +91-3326682916

b Department of Chemistry, Panskura Banamali College, Purba Medinipur, West Bengal, India

Abstract

A new “naked-eye” and ratiometric fluorescent zinc sensor (TAQ) of carboxamidoquinoline with 2-chloro-N-(quinol-8-yl)-acetamide as a receptor was designed and synthesized. The sensor TAQ shows good water solubility and high selectivity for sensing; about a 15-fold increase in fluorescence quantum yield and a 100 nm red-shift of fluorescence emission upon binding Zn2+ in aqueous HEPES buffer solution are observed. The human lung cancer cell line (A549) activity is also demonstrated.

Graphical abstract: Ratiometric and absolute water-soluble fluorescent tripodal zinc sensor and its application in killing human lung cancer cells

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Article information

DOI
https://doi.org/10.1039/C3AN00067B
Article type
Paper
Submitted
09 Jan 2013
Accepted
19 Apr 2013
First published
11 Jun 2013

Analyst, 2013,138, 4593-4598

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Ratiometric and absolute water-soluble fluorescent tripodal zinc sensor and its application in killing human lung cancer cells

S. Goswami, A. K. Das, K. Aich, A. Manna, S. Maity, K. Khanra and N. Bhattacharyya, Analyst, 2013, 138, 4593 DOI: 10.1039/C3AN00067B

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