Jump to main content
Jump to site search

Issue 14, 2013
Previous Article Next Article

Impact of mesoporous silica nanoparticle surface functionality on hemolytic activity, thrombogenicity and non-specific protein adsorption

Author affiliations

Abstract

Although numerous mesoporous silica nanoparticle (MSN) drug carriers and theranostic agents with various surface functionalities have been designed in the last decade, their biocompatibility remains a matter of intensive debate. Here, we systematically evaluated interactions of a series of MSNs possessing different surface functional groups (ionic, polar, neutral, and hydrophobic) with blood constituents, in terms of their hemolytic activity, thrombogenicity, and adsorption of blood proteins on their surfaces. Using a hemolysis assay we showed that surface functionalization can reduce or even completely prevent the hemolytic activity of bare MSNs. We investigated thrombogenicity of MSNs by measuring prothrombin time (PT) and activated partial thromboplastin time (aPTT). We observed that none of the MSNs used in this study exhibit significant thrombogenic activity. Lastly, we examined non-specific protein adsorption on MSN surfaces using human serum albumin (HSA) and gamma globulins (γGs) and found that surface functionalization with ionic groups can greatly reduce protein adsorption. Demonstration of the surface functionalization having a crucial impact on blood compatibility might serve as a guideline for further investigation related to the design of mesoporous silica systems for biomedical applications, and shed light on research towards the ultimate goal of developing smart theranostic systems.

Graphical abstract: Impact of mesoporous silica nanoparticle surface functionality on hemolytic activity, thrombogenicity and non-specific protein adsorption

Back to tab navigation

Supplementary files

Publication details

The article was received on 17 Nov 2012, accepted on 01 Feb 2013 and first published on 04 Feb 2013


Article type: Paper
DOI: 10.1039/C3TB20139B
Citation: J. Mater. Chem. B, 2013,1, 1909-1920
  •   Request permissions

    Impact of mesoporous silica nanoparticle surface functionality on hemolytic activity, thrombogenicity and non-specific protein adsorption

    A. Yildirim, E. Ozgur and M. Bayindir, J. Mater. Chem. B, 2013, 1, 1909
    DOI: 10.1039/C3TB20139B

Search articles by author

Spotlight

Advertisements