Issue 5, 2013

Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents

Abstract

Highly ordered two or three dimensional mesophases in aqueous solution could be usefully obtained by using monoolein (MO) or diolein (DO) monomers. Nanostructures (also indicated as nanoparticles, NPs) of MO or DO containing different amounts (1%, 5%, 10% and 20%) of the synthetic amphiphilic gadolinium complex (C18)2DTPA(Gd) have been prepared and characterized for their relaxometric and structural behaviors. The nanostructure is found in the 110–200 nm range for all investigated systems, while the presence of the gadolinium containing monomer produces a partial loss of the cubic symmetry, as shown by Cryo-TEM images of NPs doped with 10% w/w of (C18)2DTPA(Gd). Gadolinium containing nanostructures display high relaxivity values (in the 10–15 mM−1 s−1 range at 25° and 20 MHz, with a further increase at 37 °C for DO based NPs), and interesting relaxometric properties for their possible use as MRI contrast agents. NPs containing 10% w/w of (C18)2DTPA(Gd) (MO3-NPs and DO3-NPs) have been also derivatized by introducing 3% wt of (C18)2–Peg3000–FA to obtain targeted aggregates (MO3-NP–FA, DO3-NP–FA). A preferential uptake efficiency of DO3-NP–FA in IGROV-1 cells with respect to DO-NPs without folic acid is observed, especially when cells are incubated with low concentrations of nanostructures or at short incubation times, thus indicating its potential use as a target-selective delivery system for MRI contrast agents on tumor cells overexpressing the folate receptor.

Graphical abstract: Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents

Article information

Article type
Paper
Submitted
30 Oct 2012
Accepted
30 Nov 2012
First published
03 Dec 2012

J. Mater. Chem. B, 2013,1, 617-628

Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents

A. Accardo, E. Gianolio, F. Arena, S. Barnert, R. Schubert, D. Tesauro and G. Morelli, J. Mater. Chem. B, 2013, 1, 617 DOI: 10.1039/C2TB00329E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements