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Issue 3, 2013
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Photoreactive oligoethylene glycol polymers – versatile compounds for surface modification by thin hydrogel films

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Abstract

Solid surfaces are modified using photo-crosslinkable copolymers based on oligo(ethylene glycol) methacrylate (OEGMA) bearing 2-(4-benzoylphenoxy)ethyl methacrylate (BPEM) as a photosensitive crosslinking unit. Thin films of about 100 nm are formed by spin-coating these a priori highly biocompatible copolymers onto silicon substrates. Subsequent UV-irradiation assures immobilization and crosslinking of the hydrogel films. Their stability is controlled by the number of crosslinker units per chain and the molar mass of the copolymers. The swelling of the hydrogel layers, as investigated by ellipsometry, can be tuned by the crosslinker content in the copolymer. If films are built from the ternary copolymers of OEGMA, BPEM and 2-(2-methoxyethoxy) ethyl methacrylate (MEO2MA), the hydrogel films exhibit a swelling/deswelling transition of the lower critical solution temperature (LCST) type. The observed thermally induced hydrogel collapse is fully reversible and the onset temperature of the transition can be tuned at will by the copolymer composition. Different from analogously prepared thermo-responsive hydrogel films of photocrosslinked poly(N-isopropylacrylamide), the swelling–deswelling transition occurs more gradually, but shows no hysteresis.

Graphical abstract: Photoreactive oligoethylene glycol polymers – versatile compounds for surface modification by thin hydrogel films

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Publication details

The article was received on 13 Aug 2012, accepted on 29 Oct 2012 and first published on 19 Nov 2012


Article type: Paper
DOI: 10.1039/C2SM26879E
Citation: Soft Matter, 2013,9, 929-937
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    Photoreactive oligoethylene glycol polymers – versatile compounds for surface modification by thin hydrogel films

    J. Buller, A. Laschewsky and E. Wischerhoff, Soft Matter, 2013, 9, 929
    DOI: 10.1039/C2SM26879E

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