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Issue 28, 2013
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Pressure effects on a proteinlipid model membrane

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Abstract

We attempt to mimic cellular biomembrane structures using a mixture of two important biochemical components – a membrane protein and a lipid, in the presence of water. Protein loaded lipid structures were subjected to a wide range of pressures to examine their morphological reorganizations using synchrotron X-ray radiation under stepwise pressure variation and rapid pressure jumps. Here we report the first evidence of a highly swollen gyroid cubic phase under high pressure (gyroid type structures have been seen in ER and Golgi membranes) and the close resemblance of lipid nanostructural behavior with literature studies on compression–decompression of piezophilic biomembranes. These studies are promising for understanding complex biomembrane restructuring and hence functioning, such as how cells cope with extreme conditions of high pressures, and protect their delicate internal organelles.

Graphical abstract: Pressure effects on a protein–lipid model membrane

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Publication details

The article was received on 03 Apr 2013, accepted on 22 May 2013 and first published on 23 May 2013


Article type: Paper
DOI: 10.1039/C3SM50911G
Citation: Soft Matter, 2013,9, 6525-6531
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    Pressure effects on a proteinlipid model membrane

    C. V. Kulkarni, O. Ces, R. H. Templer and J. M. Seddon, Soft Matter, 2013, 9, 6525
    DOI: 10.1039/C3SM50911G

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