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Issue 9, 2013
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Nanopatterned polymer brushes as switchable bioactive interfaces

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Abstract

We report convenient methods for synthesis of nanopatterned, thermally responsive brushes of poly(N-isopropyl acrylamide) over large areas (e.g., 1 cm2) to form model, dynamic, biofunctional surfaces. The new nanopatterned brush structure can be used to control (i) the rate of both nonspecific and biospecific adsorption processes at the polymer-graft-free regions of the substrate, and (ii) the rate of cell detachment. These capabilities have potential implications in a number of areas of biotechnology including biosensing, separations and cell culture.

Graphical abstract: Nanopatterned polymer brushes as switchable bioactive interfaces

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Publication details

The article was received on 18 Jan 2013, accepted on 11 Mar 2013 and first published on 15 Mar 2013


Article type: Communication
DOI: 10.1039/C3NR00312D
Citation: Nanoscale, 2013,5, 3632-3637
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    Nanopatterned polymer brushes as switchable bioactive interfaces

    Q. Yu, P. Shivapooja, L. M. Johnson, G. Tizazu, G. J. Leggett and G. P. López, Nanoscale, 2013, 5, 3632
    DOI: 10.1039/C3NR00312D

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