Issue 9, 2013
From the journal:

Nanoscale

Nanopatterned polymer brushes as switchable bioactive interfaces†

Qian Yu,‡a   Phanindhar Shivapooja,‡a   Leah M. Johnson,a   Getachew Tizazu,a   Graham J. Leggettd  and  Gabriel P. López*abc  

* Corresponding authors

a Department of Biomedical Engineering, Duke University, Durham, NC, USA
E-mail: gabriel.lopez@duke.edu

b Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA

c NSF Research Triangle Materials Research Science & Engineering Center, Duke University, Durham, NC, USA

d Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, UK

Abstract

We report convenient methods for synthesis of nanopatterned, thermally responsive brushes of poly(N-isopropyl acrylamide) over large areas (e.g., 1 cm2) to form model, dynamic, biofunctional surfaces. The new nanopatterned brush structure can be used to control (i) the rate of both nonspecific and biospecific adsorption processes at the polymer-graft-free regions of the substrate, and (ii) the rate of cell detachment. These capabilities have potential implications in a number of areas of biotechnology including biosensing, separations and cell culture.

Graphical abstract: Nanopatterned polymer brushes as switchable bioactive interfaces

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Article information

DOI
https://doi.org/10.1039/C3NR00312D
Article type
Communication
Submitted
18 Jan 2013
Accepted
11 Mar 2013
First published
15 Mar 2013

Nanoscale, 2013,5, 3632-3637

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Nanopatterned polymer brushes as switchable bioactive interfaces

Q. Yu, P. Shivapooja, L. M. Johnson, G. Tizazu, G. J. Leggett and G. P. López, Nanoscale, 2013, 5, 3632 DOI: 10.1039/C3NR00312D

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