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Issue 9, 2013
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The potent antimicrobial properties of cell penetrating peptide-conjugated silver nanoparticles with excellent selectivity for Gram-positive bacteria over erythrocytes

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Abstract

Silver nanoparticles are of great interest for use as antimicrobial agents. Studies aimed at producing potent nano-silver biocides have focused on manipulation of particle size, shape, composition and surface charge. Here, we report the cell penetrating peptide catalyzed formation of antimicrobial silver nanoparticles in N,N-dimethylformamide. The novel nano-composite demonstrated a distinctly enhanced biocidal effect toward bacteria (Gram-positive Bacillus subtilis, Gram-negative Escherichia coli) and pathogenic yeast (Candida albicans), as compared to triangular and extremely small silver nanoparticles. In addition, a satisfactory biocompatibility was verified by a haemolysis test. Our results provide a paradigm in developing strategies that can maximize the silver nanoparticle application potentials while minimizing the toxic effects.

Graphical abstract: The potent antimicrobial properties of cell penetrating peptide-conjugated silver nanoparticles with excellent selectivity for Gram-positive bacteria over erythrocytes

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Publication details

The article was received on 23 Dec 2012, accepted on 26 Feb 2013 and first published on 01 Mar 2013


Article type: Paper
DOI: 10.1039/C3NR34254A
Citation: Nanoscale, 2013,5, 3834-3840
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    The potent antimicrobial properties of cell penetrating peptide-conjugated silver nanoparticles with excellent selectivity for Gram-positive bacteria over erythrocytes

    L. Liu, J. Yang, J. Xie, Z. Luo, J. Jiang, Y. Y. Yang and S. Liu, Nanoscale, 2013, 5, 3834
    DOI: 10.1039/C3NR34254A

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