Jump to main content
Jump to site search

Issue 5, 2013
Previous Article Next Article

A silver complex of chloroquine: synthesis, characterization and structural properties

Author affiliations

Abstract

A new silver–chloroquine (CQ–Ag) complex [CQAgNO3, CQ = chloroquine, C18H26N3Cl] has been synthesized and characterized by using a combination of NMR (solution and solid-state), FTIR, molar conductivity and ESI/FT-ICR high resolution mass spectroscopy with DFT calculations. The CQ–Ag complex is formed by silver–CQ cations and nitrate counter anions, where the silver atoms are di-coordinated to chloroquines (CQ22Ag2+2+) through the quinoline sp2 N and diethylamino sp3 N nitrogen basic sites. These cations presumably form polymeric structures mainly as head–head catemers. The most important cationic fragments of the CQ–Ag complex, detected by ESI/FT-ICR, were CQAg+, CQ2Ag+, chloroquine singly (CQH+) and doubly protonated (CQH22+), whose formations are clearly favored by proton-displacement of the Ag+ cations.

Graphical abstract: A silver complex of chloroquine: synthesis, characterization and structural properties

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 11 Oct 2012, accepted on 07 Feb 2013 and first published on 11 Feb 2013


Article type: Paper
DOI: 10.1039/C3NJ40921J
Citation: New J. Chem., 2013,37, 1391-1401
  •   Request permissions

    A silver complex of chloroquine: synthesis, characterization and structural properties

    J. Z. Dávalos, J. González, A. Guerrero, A. C. Valderrama-Negrón, L. D. Aguirre Méndez, R. M. Claramunt, D. Santa María, I. Alkorta and J. Elguero, New J. Chem., 2013, 37, 1391
    DOI: 10.1039/C3NJ40921J

Search articles by author