Issue 10, 2013
From the journal:

MedChemComm

Facile synthesis of a polyether-tethered dimeric berberine as a highly effective DNA-cleaving agent in the presence of Cu(ii) ion†

Yong-Min Wang,‡a   Chun-Qiong Zhou,‡a   Jin-Xiang Chen,a   Yan-Ling Lin,a   Wei Zeng,b   Bi-Cheng Kuang,a   Wei-Long Fua  and  Wen-Hua Chen*a  

* Corresponding authors

a School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, P. R. China
E-mail: whchen@smu.edu.cn

b School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China

Abstract

A polyether-tethered dimeric berberine was synthesized and found to be capable of efficiently converting pBR322 DNA into open circular and linear forms in the presence of Cu(II) ions under physiological conditions, most probably via an oxidative mechanism. Michaelis–Menten analysis afforded ca. 3.5 × 109-fold rate acceleration over uncatalyzed cleavage of supercoiled DNA. The probable mode of action is also briefly discussed.

Graphical abstract: Facile synthesis of a polyether-tethered dimeric berberine as a highly effective DNA-cleaving agent in the presence of Cu(ii) ion

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Article information

DOI
https://doi.org/10.1039/C3MD00136A
Article type
Concise Article
Submitted
15 May 2013
Accepted
16 Jul 2013
First published
18 Jul 2013

Med. Chem. Commun., 2013,4, 1400-1404

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Facile synthesis of a polyether-tethered dimeric berberine as a highly effective DNA-cleaving agent in the presence of Cu(II) ion

Y. Wang, C. Zhou, J. Chen, Y. Lin, W. Zeng, B. Kuang, W. Fu and W. Chen, Med. Chem. Commun., 2013, 4, 1400 DOI: 10.1039/C3MD00136A

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