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Issue 13, 2013
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Optimized templates for bottom-up growth of high-performance integrated biomolecular detectors

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Abstract

Electrochemical deposition of metals represents an important approach in the bottom-up fabrication of nanostructures and microstructures. We have used this approach to generate high-performance chip-based biosensors using silicon as a platform for the generation of sensor arrays. Here, we explore the applicability of different materials to support the electrodeposition and identify the parameters that are essential for robust sensor growth. We show that inexpensive materials can be used as templates for electrodeposition, and demonstrate that these low-cost sensors exhibit clinically-relevant levels of sensitivity and specificity. In particular, we prove herein that the glass-based sensors successfully detect E. coli in urine, when present at the 100 cfu μL−1 levels found typically in samples of patients with urinary tract infections.

Graphical abstract: Optimized templates for bottom-up growth of high-performance integrated biomolecular detectors

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Publication details

The article was received on 24 Dec 2012, accepted on 07 Feb 2013 and first published on 07 Feb 2013


Article type: Paper
DOI: 10.1039/C3LC41416G
Citation: Lab Chip, 2013,13, 2569-2575
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    Optimized templates for bottom-up growth of high-performance integrated biomolecular detectors

    B. Lam, R. D. Holmes, J. Das, M. Poudineh, A. Sage, E. H. Sargent and S. O. Kelley, Lab Chip, 2013, 13, 2569
    DOI: 10.1039/C3LC41416G

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