Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Tuesday 19th September 2017 from 8.00am to 4.00pm (BST).

During this time our website performance may be temporarily affected. If you have any questions please use the feedback button available under our menu button. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 4, 2013
Previous Article Next Article

A polymer-based neural microimplant for optogenetic applications: design and first in vivo study

Author affiliations

Abstract

In optogenetics, neurons are genetically modified to become sensitive to light and thus, they can be stimulated or inhibited by light of certain wavelengths. In this work, we describe the fabrication of a polymer-based shaft electrode as a tool for optogenetics. This device can conduct light as well as fluids to a target brain region and record electrical neural signals from the same part of the tissue simultaneously. It is intended to facilitate optogenetic in vivo experiments with those novel multimodal neural probes or polymer optrodes. We used microsystems technology to integrate an SU-8 based waveguide and fluidic channel into a polyimide-based electrode shaft to allow simultaneous optical stimulation, fluid delivery, and electrophysiological recording in awake behaving animals. In a first acute proof-of-concept experiment in genetically modified mice, our device recorded single unit activity that was modulated by laser light transmitted into the tissue via the integrated waveguide.

Graphical abstract: A polymer-based neural microimplant for optogenetic applications: design and first in vivo study

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 Aug 2012, accepted on 02 Jan 2013 and first published on 03 Jan 2013


Article type: Paper
DOI: 10.1039/C2LC40874K
Citation: Lab Chip, 2013,13, 579-588
  •   Request permissions

    A polymer-based neural microimplant for optogenetic applications: design and first in vivo study

    B. Rubehn, S. B. E. Wolff, P. Tovote, A. Lüthi and T. Stieglitz, Lab Chip, 2013, 13, 579
    DOI: 10.1039/C2LC40874K

Search articles by author

Spotlight

Advertisements