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Issue 4, 2013
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A polymer-based neural microimplant for optogenetic applications: design and first in vivo study

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Abstract

In optogenetics, neurons are genetically modified to become sensitive to light and thus, they can be stimulated or inhibited by light of certain wavelengths. In this work, we describe the fabrication of a polymer-based shaft electrode as a tool for optogenetics. This device can conduct light as well as fluids to a target brain region and record electrical neural signals from the same part of the tissue simultaneously. It is intended to facilitate optogenetic in vivo experiments with those novel multimodal neural probes or polymer optrodes. We used microsystems technology to integrate an SU-8 based waveguide and fluidic channel into a polyimide-based electrode shaft to allow simultaneous optical stimulation, fluid delivery, and electrophysiological recording in awake behaving animals. In a first acute proof-of-concept experiment in genetically modified mice, our device recorded single unit activity that was modulated by laser light transmitted into the tissue via the integrated waveguide.

Graphical abstract: A polymer-based neural microimplant for optogenetic applications: design and first in vivo study

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Publication details

The article was received on 01 Aug 2012, accepted on 02 Jan 2013, published on 03 Jan 2013 and first published online on 03 Jan 2013


Article type: Paper
DOI: 10.1039/C2LC40874K
Citation: Lab Chip, 2013,13, 579-588
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    A polymer-based neural microimplant for optogenetic applications: design and first in vivo study

    B. Rubehn, S. B. E. Wolff, P. Tovote, A. Lüthi and T. Stieglitz, Lab Chip, 2013, 13, 579
    DOI: 10.1039/C2LC40874K

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