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Issue 2, 2013
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Microbial evolution in vivo and in silico: methods and applications

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Abstract

Microbial evolution has been extensively studied in the past fifty years, which has lead to seminal discoveries that have shaped our understanding of evolutionary forces and dynamics. It is only recently however, that transformative technologies and computational advances have enabled a larger in-scale and in-depth investigation of the genetic basis and mechanistic underpinnings of evolutionary adaptation. In this review we focus on the strengths and limitations of in vivo and in silico techniques for studying microbial evolution in the laboratory, and we discuss how these complementary approaches can be integrated in a unifying framework for elucidating microbial evolution.

Graphical abstract: Microbial evolution in vivo and in silico: methods and applications

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Publication details

The article was received on 25 Apr 2012, accepted on 14 Sep 2012 and first published on 18 Sep 2012


Article type: Critical Review
DOI: 10.1039/C2IB20095C
Citation: Integr. Biol., 2013,5, 262-277
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    Microbial evolution in vivo and in silico: methods and applications

    V. Mozhayskiy and I. Tagkopoulos, Integr. Biol., 2013, 5, 262
    DOI: 10.1039/C2IB20095C

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