Issue 55, 2013

Functional dissection and module swapping of fungal cyclooligomer depsipeptide synthetases

Abstract

BbBSLS and BbBEAS were dissected and reconstituted in Saccharomyces cerevisiae. The intermodular linker is essential for the reconstitution of the separate modules. Module 1 can be swapped between BbBEAS and BbBSLS, while modules 2 and 3 control the product profiles. BbBSLS is a flexible enzyme that also synthesizes beauvericins.

Graphical abstract: Functional dissection and module swapping of fungal cyclooligomer depsipeptide synthetases

Supplementary files

Article information

Article type
Communication
Submitted
03 Apr 2013
Accepted
16 May 2013
First published
17 May 2013

Chem. Commun., 2013,49, 6176-6178

Functional dissection and module swapping of fungal cyclooligomer depsipeptide synthetases

D. Yu, F. Xu, D. Gage and J. Zhan, Chem. Commun., 2013, 49, 6176 DOI: 10.1039/C3CC42425A

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