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Issue 48, 2013
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Asymmetric amplification in the catalytic enantioselective 1,2-addition of Grignard reagents to enones

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Abstract

Large asymmetric amplification originating from solubility differences between the enantiopure and the racemic catalyst is observed in the addition of Grignard reagents to enones. This behaviour is not reaction or catalyst specific and is observed for metal complexes of a variety of chiral diphosphine ligands, extensively used in asymmetric catalysis.

Graphical abstract: Asymmetric amplification in the catalytic enantioselective 1,2-addition of Grignard reagents to enones

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Publication details

The article was received on 13 Mar 2013, accepted on 22 Apr 2013 and first published on 23 Apr 2013


Article type: Communication
DOI: 10.1039/C3CC41892H
Citation: Chem. Commun., 2013,49, 5450-5452
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    Asymmetric amplification in the catalytic enantioselective 1,2-addition of Grignard reagents to enones

    F. Caprioli, A. V. R. Madduri, A. J. Minnaard and S. R. Harutyunyan, Chem. Commun., 2013, 49, 5450
    DOI: 10.1039/C3CC41892H

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