Issue 45, 2013

Exploration of the medical periodic table: towards new targets

Abstract

Metallodrugs offer potential for unique mechanisms of drug action based on the choice of the metal, its oxidation state, the types and number of coordinated ligands and the coordination geometry. We discuss recent progress in identifying new target sites and elucidating the mechanisms of action of anti-cancer, anti-bacterial, anti-viral, anti-parasitic, anti-inflammatory, and anti-neurodegenerative agents, as well as in the design of metal-based diagnostic agents. Progress in identifying and defining target sites has been accelerated recently by advances in proteomics, genomics and metal speciation analysis. Examples of metal compounds and chelating agents (enzyme inhibitors) currently in clinical use, clinical trials or preclinical development are highlighted.

Graphical abstract: Exploration of the medical periodic table: towards new targets

Supplementary files

Article information

Article type
Feature Article
Submitted
11 Feb 2013
Accepted
03 Apr 2013
First published
01 May 2013
This article is Open Access
Creative Commons BY license

Chem. Commun., 2013,49, 5106-5131

Exploration of the medical periodic table: towards new targets

N. P. E. Barry and P. J. Sadler, Chem. Commun., 2013, 49, 5106 DOI: 10.1039/C3CC41143E

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