Issue 22, 2013
From the journal:

Chemical Communications

Maleimide-functionalised platinum(iv) complexes as a synthetic platform for targeted drug delivery†

Verena Pichler,‡a   Josef Mayr,‡a   Petra Heffeter,*bc   Orsolya Dömötör,d   Éva A. Enyedy,d   Gerrit Hermann,e   Diana Groza,c   Gunda Köllensperger,e   Markus Galanksi,a   Walter Berger,bc   Bernhard K. Kepplera  and  Christian R. Kowol*ab  

* Corresponding authors

a University of Vienna, Institute of Inorganic Chemistry, Waehringer Strasse 42, Vienna, Austria
E-mail: christian.kowol@univie.ac.at
Fax: +43-1-4277-52680
Tel: +43-1-4277-52609

b Research Platform “Translational Cancer Therapy Research” University of Vienna, Waehringer Strasse 42, Vienna, Austria

c Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, Vienna, Austria
E-mail: petra.heffeter@meduniwien.ac.at
Fax: +43-1-40160-957555
Tel: +43-1-40160-57557

d Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7., H-6720 Szeged, Hungary

e Division of Analytical Chemistry, Department of Chemistry, University of Natural Resources and Applied Life Sciences, Muthgasse 18, A-1190 Vienna, Austria

Abstract

Maleimide-functionalised Pt(IV) complexes with highly selective binding properties to thiol groups were synthesised as precursors for binding of thiol-containing tumour-targeting molecules like human serum albumin.

Graphical abstract: Maleimide-functionalised platinum(iv) complexes as a synthetic platform for targeted drug delivery

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Article information

DOI
https://doi.org/10.1039/C3CC39258A
Article type
Communication
Submitted
28 Dec 2012
Accepted
31 Jan 2013
First published
01 Feb 2013

Chem. Commun., 2013,49, 2249-2251

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Maleimide-functionalised platinum(IV) complexes as a synthetic platform for targeted drug delivery

V. Pichler, J. Mayr, P. Heffeter, O. Dömötör, É. A. Enyedy, G. Hermann, D. Groza, G. Köllensperger, M. Galanksi, W. Berger, B. K. Keppler and C. R. Kowol, Chem. Commun., 2013, 49, 2249 DOI: 10.1039/C3CC39258A

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