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Issue 8, 2012
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Low intensity ultrasound perturbs cytoskeleton dynamics

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Abstract

Therapeutic ultrasound is widely employed in clinical applications but its mechanism of action remains unclear. Here we report prompt fluidization of a cell and dramatic acceleration of its remodeling dynamics when exposed to low intensity ultrasound. These physical changes are caused by very small strains (10−5) at ultrasonic frequencies (106 Hz), but are closely analogous to those caused by relatively large strains (10−1) at physiological frequencies (100 Hz). Moreover, these changes are reminiscent of rejuvenation and aging phenomena that are well-established in certain soft inert materials. As such, we suggest cytoskeletal fluidization together with resulting acceleration of cytoskeletal remodeling events as a mechanism contributing to the salutary effects of low intensity therapeutic ultrasound.

Graphical abstract: Low intensity ultrasound perturbs cytoskeleton dynamics

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Publication details

The article was received on 24 Nov 2011, accepted on 09 Dec 2011 and first published on 16 Jan 2012


Article type: Paper
DOI: 10.1039/C2SM07246G
Citation: Soft Matter, 2012,8, 2438-2443
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    Low intensity ultrasound perturbs cytoskeleton dynamics

    N. Mizrahi, E. H. Zhou, G. Lenormand, R. Krishnan, D. Weihs, J. P. Butler, D. A. Weitz, J. J. Fredberg and E. Kimmel, Soft Matter, 2012, 8, 2438
    DOI: 10.1039/C2SM07246G

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