Jump to main content
Jump to site search

Issue 11, 2012
Previous Article Next Article

Nitrate as a redox co-catalyst for the aerobic Pd-catalyzed oxidation of unactivated sp3-C–H bonds

Author affiliations

Abstract

This paper describes a new method for the catalytic aerobic oxygenation of unactivated sp3-C–H bonds. This transformation utilizes Pd(OAc)2 as a catalyst in conjunction with NaNO3 as a redox co-catalyst. Both oxime ether and pyridine derivatives are effective directing groups for these reactions. The oxygen incorporated into the product derives from the solvent (acetic acid). Preliminary results show that the addition of simple NaCl to the reaction mixture results in aerobic chlorination under analogous conditions.

Graphical abstract: Nitrate as a redox co-catalyst for the aerobic Pd-catalyzed oxidation of unactivated sp3-C–H bonds

Back to tab navigation

Supplementary files

Publication details

The article was received on 22 Jun 2012, accepted on 10 Aug 2012 and first published on 30 Aug 2012


Article type: Edge Article
DOI: 10.1039/C2SC20800H
Citation: Chem. Sci., 2012,3, 3192-3195
  •   Request permissions

    Nitrate as a redox co-catalyst for the aerobic Pd-catalyzed oxidation of unactivated sp3-C–H bonds

    K. J. Stowers, A. Kubota and M. S. Sanford, Chem. Sci., 2012, 3, 3192
    DOI: 10.1039/C2SC20800H

Search articles by author

Spotlight

Advertisements