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Issue 12, 2012
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Magnetic nanoparticles for direct protein sorting inside live cells

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Abstract

This work reports the first example of the biofunctional magnetic nanoparticles as a “magnetic dock” for directly sorting proteins inside live cells. We decorate the iron oxide nanoparticles with the ligands that bind selectively to fusion proteins consisting of the proteins of interest (POIs) and the ligand receptors. Similar to protein sorting processes on vesicles, the clusters of these functionalized magnetic nanoparticles only bind to the fusion proteins via the interaction with the receptors, but exhibit little interaction to other proteins. This work demonstrates new applications of magnetic nanoparticles and may ultimately contribute to the exploration of the functions of proteins via the selective, spatiotemporal control of the proteins by a magnetic force.

Graphical abstract: Magnetic nanoparticles for direct protein sorting inside live cells

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Publication details

The article was received on 24 Apr 2012, accepted on 06 Sep 2012 and first published on 10 Sep 2012


Article type: Edge Article
DOI: 10.1039/C2SC20519J
Citation: Chem. Sci., 2012,3, 3495-3499
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    Magnetic nanoparticles for direct protein sorting inside live cells

    Y. Pan, M. J. C. Long, H. Lin, L. Hedstrom and B. Xu, Chem. Sci., 2012, 3, 3495
    DOI: 10.1039/C2SC20519J

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