Jump to main content
Jump to site search

Issue 5, 2012
Previous Article Next Article

Two-, three- and four-component coupling to form isoquinolones based on directed metalation

Author affiliations

Abstract

Benzamides undergo ortho-metalation with magnesiate bases to allow trapping with propargylic chlorides. Cyclization provides isoquinolones in a one-pot operation. Benzamides can be formed in situ from aryl Grignard reagents and isocyanates. Moreover, electrophilic trapping after cyclization introduces further complexity. Alternative cyclization conditions provide the isomeric aza-isocoumarins.

Graphical abstract: Two-, three- and four-component coupling to form isoquinolones based on directed metalation

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 24 Jan 2012, accepted on 29 Feb 2012 and first published on 29 Feb 2012


Article type: Edge Article
DOI: 10.1039/C2SC20102J
Citation: Chem. Sci., 2012,3, 1450-1454
  •   Request permissions

    Two-, three- and four-component coupling to form isoquinolones based on directed metalation

    M. I. Antczak and J. M. Ready, Chem. Sci., 2012, 3, 1450
    DOI: 10.1039/C2SC20102J

Search articles by author