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Issue 5, 2012
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Metal-free, aerobic ketooxygenation of alkenes using hydroxamic acids

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Abstract

A metal-free, radical-mediated alkene ketooxygenation is described. This four-electron alkene oxidation delivers α-oxyketones directly from simple alkenes with high levels of regio- and stereocontrol. The aerobic process capitalizes on the unique reactivity of amidoxyl radicals in intra- and intermolecular alkene additions.

Graphical abstract: Metal-free, aerobic ketooxygenation of alkenes using hydroxamic acids

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Publication details

The article was received on 09 Dec 2011, accepted on 02 Feb 2012 and first published on 03 Feb 2012


Article type: Edge Article
DOI: 10.1039/C2SC01042A
Citation: Chem. Sci., 2012,3, 1672-1674
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    Metal-free, aerobic ketooxygenation of alkenes using hydroxamic acids

    V. A. Schmidt and E. J. Alexanian, Chem. Sci., 2012, 3, 1672
    DOI: 10.1039/C2SC01042A

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