Synergistic catalysis: A powerful synthetic strategy for new reaction development

Anna E. Allen; David W. C. MacMillan

doi:10.1039/C2SC00907B

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Chemical Science

Issue 3, 2012

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Synergistic catalysis: A powerful synthetic strategy for new reaction development

Anna E. Allen^a and David W. C. MacMillan*^a

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Merck Center for Catalysis at Princeton University, Princeton, USA
E-mail: dmacmill@princeton.edu ;
Fax: +1 609 2585922 ;
Tel: +1 609 2582254

Chem. Sci., 2012,3, 633-658

DOI: 10.1039/C2SC00907B
Received 11 Nov 2011, Accepted 02 Dec 2011
First published online 25 Jan 2012

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Abstract
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Synergistic catalysis is a synthetic strategy wherein both the nucleophile and the electrophile are simultaneously activated by two separate and distinct catalysts to afford a single chemical transformation. This powerful catalysis strategy leads to several benefits, specifically synergistic catalysis can (i) introduce new, previously unattainable chemical transformations, (ii) improve the efficiency of existing transformations, and (iii) create or improve catalytic enantioselectivity where stereocontrol was previously absent or challenging. This perspective aims to highlight these benefits using many of the successful examples of synergistic catalysis found in the literature.

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