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Issue 5, 2012
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Biological stimuli and biomolecules in the assembly and manipulation of nanoscale polymeric particles

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Abstract

Living systems are replete with complex, stimuli-responsive nanoscale materials and molecular self-assemblies. There is an ever increasing and intense interest within the chemical sciences to understand, mimic and interface with these biological systems utilizing synthetic and/or semi-synthetic tools. Our aim in this review is to give perspective on this emerging field of research by highlighting examples of polymeric nanoparticles and micelles that are prepared utilizing biopolymers together with synthetic polymers for the purpose of developing nanomaterials capable of interacting and responding to biologically relevant stimuli. It is expected that with the merging of evolved biological molecules with synthetic materials, will come the ability to prepare complex, functional devices. A variety of applications will become accessible including self-healing materials, self-replicating systems, biodiagnostic tools, drug targeting materials and autonomous, adaptive sensors. Most importantly, the success of this type of strategy will impact how biomolecules are stabilized and incorporated into synthetic devices and at the same time, will influence how synthetic materials are utilized within biomedical applications.

Graphical abstract: Biological stimuli and biomolecules in the assembly and manipulation of nanoscale polymeric particles

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Publication details

The article was received on 28 Oct 2011, accepted on 10 Jan 2012 and first published on 14 Feb 2012


Article type: Perspective
DOI: 10.1039/C2SC00857B
Citation: Chem. Sci., 2012,3, 1363-1380
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    Biological stimuli and biomolecules in the assembly and manipulation of nanoscale polymeric particles

    L. M. Randolph, M. Chien and N. C. Gianneschi, Chem. Sci., 2012, 3, 1363
    DOI: 10.1039/C2SC00857B

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