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Issue 26, 2012
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Highly sensitive terahertz spectroscopy in microsystem

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Abstract

We herein present a microfluidic system dedicated to THz spectroscopy of aqueous solutions. This device is able to reach a state of the art sensitivity of 5 mg mL−1, while requiring only small sample quantities and a low power source. Hydration of BSA, lysozyme and chymotrypsine proteins is studied inside microchannels and hydration numbers are computed, showing that the developed system is well suited for quantitative analysis. Moreover, coupled with advanced chemometrics algorithms, this system can become a tool for fundamental research and for the understanding of biochemical processes. Here, the hydration shell structure is discussed by chemometric analysis of the measured absorption spectra. Two spectral behaviours are observed and can be explained by Molecular Dynamics simulations. This methodology could be considered as a key element of a lab-on-a-chip for biological liquid metrology.

Graphical abstract: Highly sensitive terahertz spectroscopy in microsystem

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Publication details

The article was received on 29 Jun 2012, accepted on 23 Aug 2012 and first published on 24 Aug 2012


Article type: Paper
DOI: 10.1039/C2RA21320F
Citation: RSC Adv., 2012,2, 10064-10071
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    Highly sensitive terahertz spectroscopy in microsystem

    S. Laurette, A. Treizebre, A. Elagli, B. Hatirnaz, R. Froidevaux, F. Affouard, L. Duponchel and B. Bocquet, RSC Adv., 2012, 2, 10064
    DOI: 10.1039/C2RA21320F

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