Issue 15, 2012

A highly active organocatalyst for the asymmetric α-aminoxylation of aldehydes and α-hydroxylation of ketones

Abstract

Enantiopure trans-3-trifluoromethylsulfonylamino-4-silyloxypyrrolidines efficiently catalyse the asymmetric α-aminoxylation of aldehydes. At 1% catalyst loading (solvent-free conditions) or at 2% catalyst loading (acetonitrile solution) aldehydes are completely converted in short reaction times leading to α-aminoxylation products with very high (96–99%) enantioselectivity.

Graphical abstract: A highly active organocatalyst for the asymmetric α-aminoxylation of aldehydes and α-hydroxylation of ketones

Supplementary files

Article information

Article type
Communication
Submitted
17 May 2012
Accepted
17 May 2012
First published
13 Jun 2012

RSC Adv., 2012,2, 6164-6166

A highly active organocatalyst for the asymmetric α-aminoxylation of aldehydes and α-hydroxylation of ketones

X. Fan, E. Alza and M. A. Pericàs, RSC Adv., 2012, 2, 6164 DOI: 10.1039/C2RA20968C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements