A highly regioselective sp3 C–H amination of tertiary amides based on Fe(II) complex catalysts

Xuerong Mao; Yuanzhao Wu; Xiaoxiang Jiang; Xunhua Liu; Yixiang Cheng; Chengjian Zhu

doi:10.1039/C2RA20707A

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A highly regioselective sp³ C–H amination of tertiary amides based on Fe(ii) complex catalysts†

Xuerong Mao,^a Yuanzhao Wu,^a Xiaoxiang Jiang,^a Xunhua Liu,^a Yixiang Cheng*^a and Chengjian Zhu*^a

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* Corresponding authors

^a Key Lab of Mesoscopic Chemistry of MOE, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China
E-mail: yxcheng@nju.edu.cn,, cjzhu@nju.edu.cn
Fax: +86-25-88317761
Tel: +86-25-83686508

Abstract

A highly regioselective sp³ C–H amination of aryl amides with N-substituted pyrrolidin-2-ones has been developed with a catalyst Fe(II) complex with TBHP as a benign oxidant. This facile method can offer rapid access to the amination reaction of N-substituted pyrrolidin-2-ones in moderate to excellent yields.

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Article information

DOI: https://doi.org/10.1039/C2RA20707A
Article type: Communication
Submitted: 18 Apr 2012
Accepted: 14 May 2012
First published: 16 May 2012

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RSC Adv., 2012,2, 6733-6735

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A highly regioselective sp³ C–H amination of tertiary amides based on Fe(II) complex catalysts

X. Mao, Y. Wu, X. Jiang, X. Liu, Y. Cheng and C. Zhu, RSC Adv., 2012, 2, 6733 DOI: 10.1039/C2RA20707A

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