Issue 10, 2012

Bis-Sonogashira cross-coupling: an expeditious approach towards long-chain, phenylene-modified 1,ω-diols

Abstract

The synthesis of long-chain, phenylene-modified 1,ω-diols can be effectively performed in 60% overall yield using the bis-Sonogashira cross-coupling with 6 mol% of PdCl2(PPh3)2 and tetrabutylammonium fluoride in a copper-, amine- and solvent-free setting followed by hydrogenation.

Graphical abstract: Bis-Sonogashira cross-coupling: an expeditious approach towards long-chain, phenylene-modified 1,ω-diols

Supplementary files

Article information

Article type
Communication
Submitted
06 Mar 2012
Accepted
08 Mar 2012
First published
09 Mar 2012

RSC Adv., 2012,2, 4052-4054

Bis-Sonogashira cross-coupling: an expeditious approach towards long-chain, phenylene-modified 1,ω-diols

S. Drescher, S. Becker, B. Dobner and A. Blume, RSC Adv., 2012, 2, 4052 DOI: 10.1039/C2RA20411H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements