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Issue 10, 2012
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Bis-Sonogashira cross-coupling: an expeditious approach towards long-chain, phenylene-modified 1,ω-diols

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Abstract

The synthesis of long-chain, phenylene-modified 1,ω-diols can be effectively performed in 60% overall yield using the bis-Sonogashira cross-coupling with 6 mol% of PdCl2(PPh3)2 and tetrabutylammonium fluoride in a copper-, amine- and solvent-free setting followed by hydrogenation.

Graphical abstract: Bis-Sonogashira cross-coupling: an expeditious approach towards long-chain, phenylene-modified 1,ω-diols

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Publication details

The article was received on 06 Mar 2012, accepted on 08 Mar 2012 and first published on 09 Mar 2012


Article type: Communication
DOI: 10.1039/C2RA20411H
Citation: RSC Adv., 2012,2, 4052-4054
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    Bis-Sonogashira cross-coupling: an expeditious approach towards long-chain, phenylene-modified 1,ω-diols

    S. Drescher, S. Becker, B. Dobner and A. Blume, RSC Adv., 2012, 2, 4052
    DOI: 10.1039/C2RA20411H

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