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Issue 2, 2012
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Micro free-flow electrophoresis with injection molded chips

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Abstract

In this work we present an approach towards economic free-flow electrophoresis chips fabricated by injection molding as mass replication process. This is achieved by the development of a free-flow electrophoresis chip design suitable for one step molding fabrication. Integrated partitioning bars are incorporated as key elements for bubble segregation. A defined open gap of 20 μm in height and 500 μm in width was integrated between the separation chamber and the electrode channels, acting as a barrier for gas bubbles while maintaining electrical contact by the fluidic junction. Additionally, we present an approach to avoid internal electrodes in FFE microchips for a facile mass production process. The injection molded thermoplastic μFFE chips are ready to use without subsequent labor-intensive implementation of membranes or comparable structures serving as salt bridges.

Graphical abstract: Micro free-flow electrophoresis with injection molded chips

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Publication details

The article was received on 11 Oct 2011, accepted on 12 Oct 2011 and first published on 16 Nov 2011


Article type: Paper
DOI: 10.1039/C1RA00874A
Citation: RSC Adv., 2012,2, 520-525
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    Micro free-flow electrophoresis with injection molded chips

    S. Köhler, C. Benz, H. Becker, E. Beckert, V. Beushausen and D. Belder, RSC Adv., 2012, 2, 520
    DOI: 10.1039/C1RA00874A

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