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Issue 11, 2012
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Triggered insulin release studies of triply responsive supramolecular micelles

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Abstract

The synthesis of a supramolecular double hydrophilic glucose responsive block copolymer (DHBC) held together by cucurbit[8]uril (CB[8]) ternary complexation and its subsequent self-assembly into micelles is described. The supramolecular block copolymer assembly consists of poly(N-isopropylacrylamide) (PNIPAAm) and poly(acrylamidophenyl boronic acid) (PAAPBA) as temperature and glucose responsive blocks, respectively, and poly(dimethylacrylamide) (PDMAAm) as a hydrophilic block. Drug release studies of insulin-loaded micelles using three external triggers were studied with release of insulin achieved by changing temperature, glucose concentration or by adding a competitive guest for CB[8]. This system offers good control over the release of insulin under physiological conditions (pH 7.4, 37 °C). These exciting results suggest that this system could be a model for a clinically relevant drug delivery vehicle for diabetic treatment.

Graphical abstract: Triggered insulin release studies of triply responsive supramolecular micelles

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Publication details

The article was received on 31 May 2012, accepted on 12 Jul 2012 and first published on 17 Aug 2012


Article type: Paper
DOI: 10.1039/C2PY20380D
Citation: Polym. Chem., 2012,3, 3180-3188
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    Triggered insulin release studies of triply responsive supramolecular micelles

    X. J. Loh, M. Tsai, J. D. Barrio, E. A. Appel, T. Lee and O. A. Scherman, Polym. Chem., 2012, 3, 3180
    DOI: 10.1039/C2PY20380D

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